Mikey Madison, born on March 25, 1999, in Los Angeles, California, is an American actress who gained prominence for her role as Manson Family member Susan "Sadie" Atkins in Quentin Tarantino's Once Upon a Time in Hollywood (2019). She further established her acting credentials with performances in the television series Better Things (2016–2022) and the horror film Scream (2022).

In 2025, Madison achieved a career milestone by winning the Academy Award for Best Actress for her portrayal of Ani in Sean Baker's Anora. The film tells the story of a Brooklyn lap dancer who becomes involved with a young Russian oligarch, navigating the complexities of their relationship. Madison's performance was lauded for its depth and authenticity, contributing to the film's critical success. Anora garnered five Oscars, including Best Picture, Best Director, Best Original Screenplay, and Best Editing.

Madison's Oscar win was considered an upset, as industry expectations had favored Demi Moore for her role in The Substance. However, Madison's momentum built after her BAFTA victory, leading to her Academy Award success. In her acceptance speech, Madison expressed gratitude towards the sex worker community, acknowledging their inspiration for her role.